Adult Recon

What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with nonsurgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years?

Chief Investigator: Mr Anish Amin
Co-Chief Investigator: Prof Andrew Duckworth
Funder: NIHR (£1,833,804.93)
Trial commenced: August 2022 (ISRCTN99042491)
Current Status: Follow-up

Trauma

Fix Or Replace Enhancing distal humeruS fracTure outcomes. A multicentre UK-wide pragmatic prospective superiority randomised controlled trial comparing total elbow replacement versus fixation in patients aged 60 years and older with a distal humerus fracture.

Chief Investigator: Prof Ben Ollivere (University of Nottingham)
Co-Chief Investigator: Prof Andrew Duckworth
Funder: NIHR (£2,030,369.63)
Trial commenced: December 2023
Current Status: Recruiting

Elderly Fixation of the Radius Radiological and Clinical Evaluation: A prospective randomised trial of surgical vs. conservative management in unstable distal radius fractures in patients aged 65 and older

Chief Investigator: Prof Andrew Duckworth
Funder: Scottish Orthopaedic Research Trust into Trauma (£100,000.00) and International Research Grant from Orthopaedic Trauma Association (OTA) (£14,554.52)
Trial commenced: February 2022 (ISRCTN95922938)
Current Status: Recruiting

Simple Olecranon Fracture Fixation: A multi-centre, parallel group, two arm, non-inferiority randomised controlled trial to compare clinical and cost-effectiveness of suture fixation versus tension band wiring for simple olecranon fracture fixation in adults

Chief Investigator: Prof Adam Watts (Edge Hill University and Wrightington Upper Limb Unit)
Co-applicant and PI: Prof Andrew Duckworth (No.1 Recruitment Site)
Funder: NIHR (£1,737,362.39)
Trial completed: December 2024 (ISRCTN87904264)

Humeral shaft fracture FIXation: A single centre prospective randomised controlled trial of operative versus non-operative management of fractures of the humeral diaphysis

Funder: Scottish Orthopaedic Research Trust into Trauma (£100,000.00)
Trial completed: October 2023 (NCT03689335)
Oliver WM, Bell KR, Carter TH, Graham C, White TO, Clement ND, Duckworth AD**, Molyneux SG**. Operative vs Nonoperative Management of Fractures of the Humeral Diaphysis: The Humeral Shaft Fracture Fixation Randomized Clinical Trial. JAMA Surg. 2025 May 1; 160(5):508-516

Medial malleolus Operative Or Non-operative: A single centre prospective randomized controlled trial of operative versus nonoperative management of associated medial malleolus fractures in unstable fracture dislocations of the ankle joint

Funder: Scottish Orthopaedic Research Trust into Trauma and Acumed® (£100,000.00)
Trial completed: August 2021 (NCT03362229)
Carter TH, Oliver WM, Bell KR, Graham C, Duckworth AD, White TO. Operative vs Nonoperative Management of Unstable Medial Malleolus Fractures: A Randomized Clinical Trial. JAMA Netw Open. 2024 Jan 2; 7(1):e2351308.